Targeting folate receptor alpha for cancer treatment
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چکیده
منابع مشابه
Targeting folate receptor alpha for cancer treatment
Promising targeted treatments and immunotherapy strategies in oncology and advancements in our understanding of molecular pathways that underpin cancer development have reignited interest in the tumor-associated antigen Folate Receptor alpha (FRα). FRα is a glycosylphosphatidylinositol (GPI)-anchored membrane protein. Its overexpression in tumors such as ovarian, breast and lung cancers, low an...
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Volume 5 • Issue 2 • 1000195 Health Care Current Reviews, an open access journal ISSN:2375-4273 In a recent issue of Neoplasia, Ponte et al demonstrated the capacity of mirvetuximab soravtansine (IMGN853), a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), to augment the in vitro and in vivo activity of approved chemotherapeutic and biologic agents used in the management of ...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2016
ISSN: 1949-2553
DOI: 10.18632/oncotarget.9651